He began participating in underground exhibitions in private apartments in Moscow and Odessa in 1982, while also studying at the Moscow Institute of Chemical Technology. With Sergei Anufriev and Pavel Pepperstein, Leiderman cofounded the Inspection Medical Hermeneutics Group in Moscow in 1987; he left the group in 1990. During 2007–2008, Leiderman was a participant of the Kapiton Group (with Andrei Monastyrski and Vadim Zakharov). He is also the author of several books of essays, fiction, and poetry, including: Notes (2013); Flower Garden (2012); and Olor (2004). In 2005, Leiderman received the Andrei Bely Prize, the most important independent literature award in Russia. Recent exhibitions include: New Works, Galerija Gregor Podnar, Berlin, 2013; HeimatKunde, Jewish Museum, Berlin, 2011; Die Ehre hüt von Jugend auf, RWE Tower and Museum Folkwang, Essen, 2010; Yuri Leiderman, Centre d’art contemporain Geneve, Geneva, 2008; and Birmingham Pattern (with Andrey Silvestrov), Ikon Gallery, Birmingham, 2007. Leiderman lives and works in Berlin.